The image of the couple kissing, posted by the reality TV star bride after her Florence ceremony, has been given the thumbs up by 2.4 million users.
Ms Kardashian and her rapper husband married at 16th-century Fort Belvedere in May.
According to Instagram, the most liked image during 2014 was Kim Kardashian’s wedding post in May that received more than 2.4 million likes. It is also the most liked image ever posted on the four-year-old app.
Instagram has revealed the image of their embrace attracted the most likes this year and also the most since the picture-sharing app was launched more than four years ago.