Barry and Monica Gamble asked their guests to join them at the Virginia Blood Services Donor Center in Richmond, Virginia.
The couple requested that instead of traditional wedding gifts from a registry, friends and family donate blood.
Barry and Monica Gamble donated blood platelets in their wedding attire. The two are regular blood donors.
Barry said: "We weren’t into the whole registry thing. We figured gifts would be nice but it would be even nicer if our friends and family could help us save some lives."
Monica added, "People seemed really excited about it. Not all our friends and family are eligible to give blood but they really support the idea. So we have a mix of donors and supporters here today."
A half dozen people were able to donate blood with some traveling to Virginia from Florida and Indiana.
"The greatest gift of all is life…This is a lot more important than a toaster," Barry said.
The donation center was incredibly grateful for the newlyweds’ gesture. The donation room had wedding decorations and guests were treated to cake as the after donation snack.
Michelle Westbay, spokeswoman for the Virginia Blood Services said: "We are so thankful for their support for blood donation and sharing the opportunity for others to give the gift of life and provide hope, strength and courage to patients in need. We thank them for making us a part of their celebration and introducing others to the importance of donating blood. Through their simple act of giving, lives were impacted and forever changed."